Accession Number:

ADA459964

Title:

Novel Angiogenic Domains: Use in Identifying Unique Transforming and Tumor Promoting Pathways in Human Breast Cancer

Descriptive Note:

Final rept. 15 Sep 2000-14 Sep 2004

Corporate Author:

SCRIPPS RESEARCH INST LA JOLLA CA

Personal Author(s):

Report Date:

2004-10-01

Pagination or Media Count:

72.0

Abstract:

Breast cancers in humans often grow slowly or even remain undetectable for long periods of time only to reappear in discreet stages as progressively more malignant tumors. Recently studies in both human cancers and experimental cancers in animals have established that cancers become progressively more aggressive in incremental steps that result from genetic mutations or switches in the tumor cells themselves. We have found that the two growthdifferentiation promoting cytokines pleiotrophin PTN and midkine MK act as switches when introduced into breast cancer cells to stimulate more aggressive growth and induce new intratumor blood vessel formation, ie, an angiogenic switch. Different studies have found constitutive expression of either the PTN or MK genes in over 50 of human breast cancers, suggesting our data is very important and relevant to human breast cancer. We now plan to pursue the mechanism of PTN signaling in both MMTV driven pleiotrophin gain of function mice and knock-out pleiotrophin mice developed in the laboratory and the mechanisms of downstream PIN signaling with different chip technology-driven strategies available to us in the laboratory.

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE