Accession Number:

ADA459897

Title:

Simulation of Biomolecular Nanomechanical Systems

Descriptive Note:

Final rept. Aug 2001-Dec 2005

Corporate Author:

CALIFORNIA UNIV REGENTS BERKELEY

Report Date:

2006-10-01

Pagination or Media Count:

34.0

Abstract:

This report documents results from the BioNEMS project. Computer simulation methods and theoretical tools that can be applied to guide the design of microdevices relying on the concept of translating biomolecular binding to mechanical forces were developed. These computational tools were applied, in synergy with experiments, to define the important factors that determine device performance. One important result is that molecular-level self assembly of probe molecules determines microdevice performance, and this has had a big impact on the design of cantilever-based microdevices. These findings were used to establish design guidelines and utilized in the fabrication of a prototype device that is being transitioned in to a commercial product. Efforts to translate mechanical signals to electronic ones are also described in this context. New discoveries regarding how T lymphocytes of the immune system detect pathogens can be exploited to create synthetic pathogen detectors that exhibit extraordinary sensitivity and selectivity were examined. Computer simulations exploring T cell signaling were completed as part of this research.

Subject Categories:

  • Biochemistry
  • Chemical, Biological and Radiological Warfare
  • Miscellaneous Detection and Detectors
  • Bionics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE