Three Dimensional Reconstruction Algorithm for Imaging Pathophysiological Signals Within Breast Tissue Using Near Infrared Light
Annual summary rept. 15 Jun 2003-14 Jun 2006
DARTMOUTH COLL HANOVER NH
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Near Infrared NIR tomography is an imaging technique that aims to image optical properties of biological tissue. This technique has been used to image and characterize breast tissue in healthy volunteers as well as detecting tumor in patients. Image reconstruction algorithms have been developed, which utilizes inherent wavelength dependant a-priori information spectral as well as concurrently measured MRI structural information spatial to show that the quantitative and qualitative accuracy is dramatically improved to provide clinically useful information. Three dimensional models have been developed that will allow the use of correct size and shape of the breast being imaged, reducing image artifacts by the use of correct assumptions about the model of the breast. Novel models have also been developed that will account for otherwise ignored Refractive Index distribution of breast tissue, and the results indicate that providing the RI distribution of breast tissue is not extremely heterogeneous, the impact on reconstructed artifacts is minimal. Finally a model that demonstrates the use of exogenous fluorescent agents for imaging has also been developed.
- Medicine and Medical Research
- Infrared Detection and Detectors