Accession Number:

ADA459737

Title:

Characterization of Genetic Modifiers of Estrogen-Induced Mammary Cancer

Descriptive Note:

Annual summary rept. 1 Jul 2003-30 Jun 2006

Corporate Author:

NEBRASKA UNIV MEDICAL CENTER OMAHA

Personal Author(s):

Report Date:

2006-07-01

Pagination or Media Count:

10.0

Abstract:

Prolonged exposure to estrogens is considered a major risk factor for development of breast cancer. When treated with the naturally occurring estrogen, 17 -estradiol, ACI rats develop mammary cancers in over 90 of the population at risk. Genetic crosses between the susceptible ACI rat and resistant Copenhagen COP or Brown Norway BN rats identified a region on chromosome 5 Emca1 that modified the development of estrogen-induced mammary cancer. The purpose of this research is to determine the role of Emca1 in the development of mammary cancer. To define the role of Emca1 in the development of mammary cancer, a congenic line was developed ACI.BN-Emca1 in which the resistant BN allele of Emca1 was introgressed onto an ACI background. To determine the number of modifiers that reside within Emca1, four additional congenic lines that encompass overlapping regions of RNO5 within the Emca1 region were developed. Characterization of these congenic lines indicated that at least three modifiers of estrogen-induced mammary cancer reside within Emca1. Analysis of microarray data identified ten genes that may modify estrogen-induced mammary cancer within Emca1.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE