Accession Number:

ADA459736

Title:

Enhancing Bone Accretion Using Short Duration, Low-Level Mechanical Vibrations

Descriptive Note:

Annual rept. 26 Sep 2004-25 Sep 2005

Corporate Author:

STATE UNIV OF NEW YORK AT STONY BROOK RESEARCH FOUNDATION

Personal Author(s):

Report Date:

2005-10-01

Pagination or Media Count:

7.0

Abstract:

The etiology of the stress fracture syndrome is incompetely understood but it is clear that skeletons with high peak bone quantity and quality will be better pretected against incurring this crippling condition. In our one-year report, the ability of low-level whole body vibrations to decrease the levels of osteoclastic resorption and to enhance osteoblastic activity in the adolescent mouse skeleton, in the absence of detrimental side-effects on growth or the chemical composition of the matrix, was described. In this second annual report, data are presented that indicate that the efficacy of extremely low-level whole-body mechanical vibrations can be enhanced by altering the number of daily loading sessions or the magnitude of the acceleration. In summary, an extremely low-level mechanical stimulus, inducing deformations orders of magnitude below those that can actually damage bone, is capable of decreasing bone resorption and enhancing bone morphology effects that may help to reduce the incidence of stress fractures and to avoid skeletal pathologies later in life.

Subject Categories:

  • Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE