Monitoring Cancer Oxygenation Changes Induced by Ultrasound
Annual summary rept. 15 Jun 2002-14 May 2006
CONNECTICUT UNIV STORRS
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Chemotherapy is becoming more important in breast cancer treatment. It offers a perfect opportunity to evaluate the utility of newer targeted drugs. Despite the development of new techniques to characterize the biologic features of breast tumors, the factors influencing the quality of response to therapy remain obscure. One factor that may influence response to systemic chemotherapy is tumor perfusion. Tumors with relatively poor perfusion may receive inadequate delivery of systemic therapy. This lack of blood flow to the tumor may be a factor in poor response to intravenous chemotherapy. Furthermore, under perfused tumors may be hypoxic. Hypoxia has been implicated in the induction of biologic features associated with aggressive behavior and poor response to various forms of chemotherapy. Our hypotheses were a Tumor blood vessels were leaky and therefore acoustic vibration can be used to modulate the leaky vessels and induce oxygenation changes and improve tumor oxygenation and bThe oxygenation changes can be detected by optical measurements. Preliminary studies with 5 tumor-bearing rats demonstrated that ultrasonic vibrations could either generate significant effects early-stage tumors on optical measurements or no effects on optical measurements late-stage tumors.
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