Generation of Advanced Diagnostics and Countermeasures for Individuals Most Vulnerable to Biothreats
Final rept. 2 Apr 2001-28 Feb 2006
LOUISVILLE UNIV RESEARCH FOUNDATION INC KY OFFICE OF GRANTS MANAGEMENT
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In the first phase of this proposal, we identified mouse strains differentially resistant and susceptible to infection with three biothreat pathogens, Cowpox, Influenza, and Anthrax. In the second phase, the scope of our project is to identify 1. Host-Oriented Pathogen Response HOPR Signaling Pathways, as the underlying mechanism responsible for host-specific susceptibility and 2. the specific protein constellations responsible for the resistant or susceptible phenotypes. Pinpointing the specific proteins responsible for the host responses will allow us to develop specific drugs to convert susceptible into resistant phenotypes. Out ultimate goal is to use the knowledge and enabling technology gained for advanced diagnosis and countermeasures to biothreats.
- Medicine and Medical Research
- Chemical, Biological and Radiological Warfare