Accession Number:

ADA459265

Title:

Population Based Assessment of MHC Class 1 Antigens Down Regulation as Marker in Increased Risk for Development and Progression of Breast Cancer From Benign Breast Lesions

Descriptive Note:

Annual rept. 1 Jan 2005-31 Dec 2005

Corporate Author:

HENRY FORD HEALTH SYSTEM DETROIT MI

Personal Author(s):

Report Date:

2006-01-01

Pagination or Media Count:

42.0

Abstract:

Despite advances in chemotherapy and radiation therapies, advanced breast cancer still carries a high mortality rate. The need for effective therapies is urgent. The overall aim of this research proposal is to recognize early markers of disease and their interaction with other epidemiological risk factors that can serve as risk indicators for subsequent development of breast cancer from precancerous lesions and as prognostic markers for progression from primary to metastatic disease. The major histocompatibility complex MHC class I molecules are found on the cell membrane of all cells in the body and are involved in intercellular communications and in complex interactions with the immune system. Cancer cells with reduced or aberrant MHC molecules have been shown to evade immune surveillance and become selected for cancer progression and spread of disease to distant sites of the body. About half of all breast cancers have complete loss or reduced level of MHC class I molecules and this finding has been associated with increased tumor invasiveness and more aggressive cancers with poorer outcome. The results of our investigation to assess the role of HLA class 1 in breast cancer progression are as follows 1 formalin-fixed paraffin tissues represent a useful substrate upon which to monitor HLA antigen expression in malignant lesions, especially when appropriate markers are used to differentiate malignant cells from lymphocytes and dendritic cells 2 there was a significant correlation of expression levels of HC10 and LGII and breast lesion type pointing in the direction of upregulation in tumor cells, rather than downregulation as commonly reported 3 The results do not point to an association between HC10 abnormalities and stage 4 There is a significant trend towards lesion severity and high lymphocytic infiltration.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE