Molecular Basis of Essential Thrombocytosis
Annual rept. 18 May 2005-17 May 2006
STATE UNIV OF NEW YORK AT STONY BROOK RESEARCH FOUNDATION
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Human blood platelets play critical roles in normal hemostatic processes and pathologic conditions such as thrombosis i.e. cardiovascular disease and stroke, vascular remodeling, inflammation, and wound repair. Despite the biological importance of platelets and their intact protein synthetic capabilities, remarkably little is known about platelet mRNAs. The pathogenesis of essential thrombocytosis ET, a disease of platelet number and function, is poorly understood at the molecular level. The main goal of this project is to build on our preliminary data that suggests that patients with ET have distinct platelet transcript profiles that differ from those of normal platelets. The three main hypotheses to be tested are 1 patients with ET have mRNA profiles that are distinct from those of normal controls 2 these differences can be used to elucidate the molecular basis of ET and 3 these differences can be used to differentiate ET from other causes of thrombocytosis ET diagnostics. Completion of the specific aims as outlined below should i provide considerable insight into the molecular basis of ET, ii assist with molecular diagnostics, and iii help to devise rational approaches for pharmacological intervention.
- Anatomy and Physiology
- Medicine and Medical Research