Bone Mineral Density, Sex Steroid Genes, Race and Prostate Cancer Risk
Final rept. 1 Sep 2001-31 Aug 2006
PITTSBURGH UNIV PA
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The goal of this project is to determine whether bone mineral density assumed to be an integrated marker of sex steroid hormone exposure is a risk factor for prostate cancer and 2 to identify prostate cancer susceptibility alleles among genes in the sex steroid pathway. To address these aims, we undertook a case-control study of African American and Caucasian men in Pittsburgh, PA and Birmingham, AL. As of 6131106, 234 Caucasian and 56 African American AA cases and 237 Caucasian and 67 AA controls with PSA 3.0 ngImL frequency matched by age and race to Hip, spine and total body BMD is measured by Dual-energy X-ray Absorptiometry DXA on all particpants. Blood specimens have been used to isolate DNA on all subjects. Polymerase Chain Reaction PCR techniques were used to determine allelic distributions of genotypes for sex steroid metabolism, biosynthesis and action genes. Risk factor data were obtained by an in-person interview and are immediately scanned into the study database. All data collection is complete and we are now analyzing the data. We will evaluate the role of BMD and candidate genotypes in prostate cancer risk by race. We will further examine the interaction between BMD and genotypes to evaluate the hormonal environment - gene interaction and its effect on prostate cancer risk.
- Medicine and Medical Research