Refining Functional Optical Imaging of the Breast with Quantum Dots
Final rept. 15 Jul 2004-14 Jul 2006
SCRIPPS INSTITUTION OF OCEANOGRAPHY LA JOLLA CA
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The Quantum Dot Corporation has recently completed the development of a QD which emits in the near infrared NIR QD 705 Streptavidin Conjugate, which can be excited at 633 nm. One step towards using QDs as a functional imaging agent were realized by linking them to immunoglobulin G and Streptavidin where it was demonstrated that the QDs could be used to label the breast cancer marker Her2 on the surface of live cancer cells. This report documents a set of lab experiments on gelatin phantoms that were designed to look at the potential for enhanced imaging of QDs. Our method of choice consisted of using ultrasound in order to label them. A bench top system for testing the use of ultrasound to modulate potential specimens was assembled. Recorded data from specimen preparations in the presence and absence of QDs were recorded. Results indicate that the modulated light from QDs can be observed, however is substantially weaker than that observed from the elastically scattered light at 532 nm. The potential use of Acoustic Modulation for increased resolution of QDs is therefore possible.
- Medicine and Medical Research
- Quantum Theory and Relativity