Mitochondrial Structure and Reactive Oxygen Species in Mammary Oncogenesis
Annual rept. 31 Mar 2005-30 Mar 2006
NORTHERN CALIFORNIA INST FOR RESEARCH AND EDUCATION SAN FRANCISCO
Pagination or Media Count:
Oxidative stress may play a role in human oncogenesis, including breast cancer. The mitochondria are most common sources of reactive oxygen species ROS responsible for most oxidative stress. This project evaluates the role of mitochondrial abnormalities in oxidative stress in breast cancer development. Transgenic mice harboring mutant mitochondrial Complex II subunit targeted in the mammary glands will be characterized in terms of mitochondrial functions, ROS production and oncogenesis. The effects of oxidative stress in other transgenic mouse models of breast cancer or predisposed mice will be generated by cross-breeding and analyzed in terms of their courses of oncogenesis in the presence or absence of the mitochondrial mutant transgene, and hence oxidative stress. This study should provide significant information regarding the role of oxidative stress in breast cancer development and progression, and insights on whether antioxidants are beneficial in prevention and treatment of such important cancer in women.
- Medicine and Medical Research