An Evaluation of Stereoscopic Digital Mammography for Earlier Detection of Breast Cancer and Reduced Rate of Recall
Annual rept. 1 Aug 2005-31 Jul 2006
BBN TECHNOLOGIES CAMBRIDGE MA
Pagination or Media Count:
The goal of this project is to evaluate in a screening context stereoscopic digital mammography versus standard non-stereo digital mammography for earlier detection of breast lesions during screening and for reductions in the rate of patient recall for further work-up. At the end of the fourth year of the project we have enrolled 585 patients into the clinical trial. Following independent reading of the standard and stereo screening mammograms 115 patients 19.7 were recalled for work-up studies of 141 reported findings 60 from standard mammography alone 45 from stereo mammography alone and 36 reported by both. Work-up examinations confirmed 62 of the reported findings as true positivesincluding 15 cancers and 79 as false positives. With regard to true positive findings detection sensitivity standard mammography detected 46 and missed 16 stereo mammography detected 49 and missed 13-an improvement in sensitivity of 6.5. With regard to detection specificity standard mammography reported 50 false positive lesions while stereo mammography reported only 32-a highly significant reduction of 36 in the rate of false positive detections p.005. Thus at this stage of the clinical trial stereo mammography is demonstrating a modest improvement in sensitivity and a remarkable improvement in specificity relative to standard mammography.
- Medicine and Medical Research