Toward High Magnetic Moment, Controlled-Size, Blood Dispersible Nanoparticles: An Enabling Technology for Biomagnetics Interfacing Concepts
Final rept. 15 May 2005-2 Mar 2006
VIRGINIA POLYTECHNIC INST AND STATE UNIV BLACKSBURG DEPT OF CHEMISTRY
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We have developed a productive alliance with Drs. Kaminski and Mertz from the Argonne National Laboratories and with Dr. Rosengart from the University of Chicago, who have designed a unique, portable, blood detoxification device with the goal of magnetically filtering undesirable components from the blood stream. Our group has supported their DARPA-AFOSR project entitled Biohazard Detoxification Method Utilizing Magnetic Particles by providing materials and materials guidance. Our focus during the current year has been on achieving biodegradable nanospheres in the 100-500 nm diameter size range which contain high concentrations of magnetite. The current status of this work is that we have polyD,L-lactide nanospheres which contain 40 weight percent magnetite. The average nanosphere diameter is approximately 80-90 nm. We have incorporated one weight percent of a 2k-20k Mn polyethylene oxide-b-D,L-lactide block copolymer into the nanospheres in efforts to achieve hydrophilic surfaces. The current focus is on 1 learning how to increase the nanosphere size slightly to achieve 100-500 nm particles, 2 achieving even higher concentrations of magnetite, and 3 understanding how to achieve surfaces sufficiently covered with polyethylene oxide with this nanosphere process to avoid immune response. We will collaborate with KaminskiMertzRosengart to relate nanosphere composition and processing to immune response.
- Medicine and Medical Research
- Chemical, Biological and Radiological Warfare