Accession Number:

ADA458543

Title:

Development of a PBPK Model for JP-8

Descriptive Note:

Final rept. 1 Mar 2003-30 Sep 2006

Corporate Author:

GEORGIA UNIV ATHENS

Report Date:

2006-11-15

Pagination or Media Count:

16.0

Abstract:

The overarching goal of this research project was to develop a mathematical dosimetry model for aerosolized JP-8 to better understand human exposure to inhaled JP-8. The JP-8 dosimetry model could then be used to determine human health risks from exposure to JP-8. For the first time, individual hydrocarbon data were collected to characterize the atmospheric exposures and dosimetry for laboratory animals exposed to vaporized or aerosolized JP-8. Both chamber atmosphere and body burden data were collected using analytical methods developed by our team. Our dosimetry work was curtained at end of this grant and remains to be completed. However, preliminary findings suggest that important differences in exposure of rats to individual hydrocarbons occur when JP-8 is aerosolized vs vaporized. This provide some evidence for explaining the apparent discrepancies reported for the toxicology of JP-8 when exposed to vapor vs. aerosolvapor mixtures.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology
  • Fuels

Distribution Statement:

APPROVED FOR PUBLIC RELEASE