Accession Number:

ADA458449

Title:

Carcinogenicity and Immunotoxicity of Embedded Depleted Uranium and Heavy-Metal Tungsten Alloy in Rodents

Descriptive Note:

Final rept. 17 Sep 2001-16 Sep 2006

Corporate Author:

HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE ROCKVILLE MD

Report Date:

2006-10-01

Pagination or Media Count:

73.0

Abstract:

This study investigated the carcinogenic and immunotoxic potential of embedded fragments of depleted uranium DU and a heavy-metal tungsten alloy WA consisting of tungsten, nickel, and cobalt. Male Fisher 344 rats were surgically implanted with pellets of DU, WA, tantalum inert metal, negative control, or nickel known carcinogen, positive control. Implanted WA resulted in the rapid formation of tumors, identified as rhabdomyosarcomas, surrounding the pellets. These tumors had, within the same area, histopathological characteristics of both the pleomorphic and embryonal subtypes of rhabdomyosarcomas. Eventually these tumors metastasized to the lung. Rats implanted with tantalum or DU pellets did not develop tumors at the implantation site. In addition, WA-implanted rats high-dose group exhibited splenomegaly and hematological changes suggesting polycythemia as early as 1 month after pellet implantation.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology
  • Inorganic Chemistry
  • Properties of Metals and Alloys

Distribution Statement:

APPROVED FOR PUBLIC RELEASE