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Dietary Fat, Eicosanoids and Breast Cancer Risk

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Annual rept. 1 Apr 2005-31 Mar 2006

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Epidemiological and animal studies associate high levels of dietary fat with increased risk of sex hormone mediated cancer, such as breast cancer. A high intake of total fat and omega-6 fatty acids increases risk while omega-3 n3 fatty acids are associated with risk reduction. Our proposal is testing the effect of dietary fat and fatty acids on sex hormone concentrations in post-menopausal women. The objectives are to evaluate 1 the effects of total fat and n3 intake on plasma and urinary sex hormone levels, 2 the relationship between plasma fatty acids and plasma and urinary sex hormones, and 3 the effects of total fat and n3 on the association between sex hormone concentrations and urinary prostaglandin E2 PGE2. We are performing a randomized, Latin square-designed controlled feeding study testing High Fat, Low Fat, and Low Fat n3 diets, each of 8 week duration. In order to determine the estrogenic effects of the diets, sex hormone endpoints will be measured reflecting availability, metabolism, and action. Plasma fatty acids fractions and urinary PGE2 will be measured to evaluate mechanistic effects. At present 48 women have been screened by telephone, 16 have been screened in the clinic and 12 are currently enrolled in the trial. Eight subjects have completed all aspects of the trial. Initial data analysis is being started this summer of the sex hormone samples. No data has yet been generated.

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  • Anatomy and Physiology
  • Medicine and Medical Research

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