Genetic Influence on Toxicity and Prognosis in Women Treated with Breast Conserving Surgery and Radiation Therapy
MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
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Women with earlier stage breast cancer who receive breast conserving surgery and radiation therapy have a generally good prognosis. However, among 15-20 of these women, breast cancer recurs, and a similar proportion of women also experience severe toxicity with radiation therapy. It is possible that inter-individual differences in capabilities of both tumor and normal cells to protect themselves from radiation-induced damage, and to repair that damage if it does occur, will influence recurrence and toxicity. This variability results from common genetic polymorphisms. This study is conducted in a well-characterized cohort of women who had breast-conserving surgery followed by radiation therapy, and in whom skin reactions were measured and noted. We have extracted DNA from blood to determine genetic polymorphisms in a number of genes that may be important in response to treatment. By conducting follow-up on the women in the study, we will be able to determine how variability in genes that protect cells from damage and in those that repair DNA damage will affect both breast cancer recurrence and toxicity experienced. Follow-up through clinic visits, letters, and home visits has been completed. We evaluated and identified effects of certain genetic polymorphisms on the occurrence of acute toxicity and in the next year, we will correlate genotyping results with late toxicity.
- Anatomy and Physiology
- Medicine and Medical Research