Accession Number:

ADA458252

Title:

Suppression of Prostate Tumor Progression by Bin 1

Descriptive Note:

Final rept., 12 Jan 2004-11 Jan 2006

Corporate Author:

LANKENAU INST OF MEDICAL RESEARCH WYNNEWOOD PA

Personal Author(s):

Report Date:

2006-02-01

Pagination or Media Count:

15.0

Abstract:

This project investigated the role of Bin 1, a gene encoding a Myc-interacting adapter protein with features of a tumor suppressor on the normal development or neoplastic transformation of the mouse prostate. In Aim 1 we determined the effect of deleting Bin 1 on normal prostate development and tumorigenesis tumor suppressor model. In Aim 2 we determined the effect of Bin 1 deletion on neoplastic progression of lesions initiated by a prostate-specific c-Myc gene negative modifier model. In Year 1 we showed that deletion of the conditional floxed allele of Bin 1 phenocopied deletion of the wild-type allele as anticipated. However, to overcome difficulties that arose in Year 2 with generating prostate-specific deletions we created mosaic animals for the study. Although studies are as yet incomplete, results collected to date in Year 3 suggest that Bin 1 loss does not increase prostate cancer incidence nor does it drive progression of Myc-initiated cancers. Ongoing experiments test whether I. Bin 1 loss limits castration-induced apoptosis in normal prostate cells andor II. Bin 1 loss phenocopies Myc activation during progression of Ras-driven cancers based on findings about the effects of Bin 1 on Myc stability emerging from other projects in Year 3.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE