Accession Number:

ADA458249

Title:

The Impact of Exercise on the Vulnerability of Dopamine Neurons to Cell Death in Animal Models of Parkinson's Disease

Descriptive Note:

Annual rept. 16 Jun 2005-15 Jun 2006

Corporate Author:

PITTSBURGH UNIV PA

Report Date:

2006-07-01

Pagination or Media Count:

10.0

Abstract:

Parkinsons disease results in part from the loss of dopamine neurons. We hypothesize that exercise reduces the vulnerability of dopamine neurons to neurotoxin exposure, whereas stress increases vulnerability. We have outlined experiments to test this hypothesis in rats treated with one of several neurotoxins, beginning with 6-hydroxydopamine. Over the past year, we increased the size and training of our research team and made a number of observations of direct relevance to our hypothesis. We also have received permission to expand our original Statement of Work to include critical studies on the mechanism of the actions of exercise, using both in vivo and in vitro approaches. Our focus continues to be on the effects of stress and exercise on the vulnerability of DA neurons, and the role played in these phenomena by trophic factors and intracellular signaling cascades.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE