Chemo Resistance of Breast Cancer Stem Cells
Annual rept. 2 Apr 2005-1 Apr 2006
MICHIGAN UNIV ANN ARBOR
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This past year was the second year of the DOD award. Over this year we have made substantial progress in achieving the goals outlined in the proposal. In addition, we have found that the enzyme aldehyde dehydrogenase 1 is an excellent marker for cancer stem cells which can be readily detected in fixed histological sections. Development of this new tool will greatly facilitate future studies. Preliminary results both in xenograft models as well as in neoadjuvant trial are providing strong support for our hypothesis for resistance of cancer cells to chemotherapy. We have also made excellent progress at elucidating the pathways which regulate the cells including Hedgehog signaling and Bmi-1. Together these studies provide a rationale for the combination compounds which inhibit stem cell renewal pathways such as Hedgehog with chemotherapeutic agents.
- Anatomy and Physiology
- Medicine and Medical Research