Accession Number:

ADA456986

Title:

The Role of C-FLIP(L) in Regulating Apoptotic Pathways in Prostate Cancer

Descriptive Note:

Annual rept. 15 Nov 2004-14 Nov 2005

Corporate Author:

BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA

Personal Author(s):

Report Date:

2005-12-01

Pagination or Media Count:

7.0

Abstract:

Abnormalities in programmed cell death apoptosis machinery play a crucial role in the initiation, progression, and metastasis of prostate cancer. Therefore, molecules that initiate pro-apoptotic pathways are excellent therapeutic agents in prostate cancer. However, some prostate cancer cells develop resistance to pro-apoptotic agents. In this proposal, the authors are examining the regulatory mechanisms of c-FLIPL, which is an important modulator of apoptosis in prostate cancer.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE