The Role of C-FLIP(L) in Regulating Apoptotic Pathways in Prostate Cancer
Annual rept. 15 Nov 2004-14 Nov 2005
BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA
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Abnormalities in programmed cell death apoptosis machinery play a crucial role in the initiation, progression, and metastasis of prostate cancer. Therefore, molecules that initiate pro-apoptotic pathways are excellent therapeutic agents in prostate cancer. However, some prostate cancer cells develop resistance to pro-apoptotic agents. In this proposal, the authors are examining the regulatory mechanisms of c-FLIPL, which is an important modulator of apoptosis in prostate cancer.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research