Accession Number:

ADA456909

Title:

Rational Inhibitors of DNA Base Excision Repair Enzymes: New Tools for Elucidating the Role of BER in Cancer Chemotherapy

Descriptive Note:

Annual summary 21 Apr 2003-20 Apr 2006

Corporate Author:

JOHNS HOPKINS UNIV BALTIMORE MD

Personal Author(s):

• Krosky, Daniel J.

Report Date:

2006-05-01

Pagination or Media Count:

22.0

Abstract:

In this funding period we have extended our studies outlined in Tasks 1 and 2 of the approved Statement of Work with the development of a novel and versatile strategy to synthesize focused chemical libraries against DNA repair enzymes. A high-throughput screen of this focused library yielded several potent and specific inhibitors of human uracil DNA glycosylase. Investigations into the effects of inhibiting uracil DNA glycosylase with these small molecules on the cytotoxicity and mechanism of 54luorouracil are ongoing. This work has resulted in two publications during this funding period.

Descriptors:

• *ENZYMES
• *DEOXYRIBONUCLEIC ACIDS
• *CANCER
• *CHEMOTHERAPY
• MOLECULES
• BREAST CANCER
• REPAIR
• INHIBITORS
• POTENCY

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE