Accession Number:

ADA456903

Title:

Effect of HER-2/NEU Signaling on Sensitivity to Trail in Prostate Cancer

Descriptive Note:

Annual rept. 1 Jun 2005-31 May 2006

Corporate Author:

PITTSBURGH UNIV PA

Personal Author(s):

Report Date:

2006-06-01

Pagination or Media Count:

11.0

Abstract:

The long-term goal of our research project is to develop a novel therapy for HER-2neu overexpressing prostate cancer. Previous studies have shown that the HER-2neu homodimer constitutively activates the PI3K-Akt-NF-kB single transduction pathway. In this budget period, we examined whether quercetin, a P13K inhibitor, promotes TRAIL cytotoxicity by inhibiting Akt activity. As DU-145 cells were treated with quercetin, we observed that TRAIL-induced cytotoxicity was promoted.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE