Accession Number:

ADA456896

Title:

Targeting of an Antimetastatic and Antiangiogenic Compound to Breast Tumors

Descriptive Note:

Annual summary rept. 15 May 2002-15 2006

Corporate Author:

BURNHAM INST LA JOLLA CA

Personal Author(s):

Report Date:

2006-07-01

Pagination or Media Count:

10.0

Abstract:

Anastellin is a fragment of fibronectin which inhibits angiogenesis, tumor growth, and metastasis in vivo, but the mechanisms behind these effects were previously unknown. We have shown that anastellin co-localizes with Annexin V, a marker for anionic phospholipids on the surface of tumor blood vessels in vivo. Anastellin potentially uses the increased levels of phosphatidylserine on the surface of proliferating endothelial cells in angiogenic blood vessels to bind to the membrane and lyse the cell, leading to its anti-angiogenic effect in tumors.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE