Targeting of an Antimetastatic and Antiangiogenic Compound to Breast Tumors
Annual summary rept. 15 May 2002-15 2006
BURNHAM INST LA JOLLA CA
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Anastellin is a fragment of fibronectin which inhibits angiogenesis, tumor growth, and metastasis in vivo, but the mechanisms behind these effects were previously unknown. We have shown that anastellin co-localizes with Annexin V, a marker for anionic phospholipids on the surface of tumor blood vessels in vivo. Anastellin potentially uses the increased levels of phosphatidylserine on the surface of proliferating endothelial cells in angiogenic blood vessels to bind to the membrane and lyse the cell, leading to its anti-angiogenic effect in tumors.
- Medicine and Medical Research