Identifying Molecular Targets for Chemoprevention in a Rat Model
Annual rept. 15 Nov 2005-14 Nov 2005
CALIFORNIA UNIV DAVIS
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The purpose of this grant is to determine the molecular events that occur in the dorsal and ventral lobes of the rat prostate gland after 20 weeks of exposure to PhIP 2-amino-i -methyl-6-phenylimidazo4,5-bpyndene. PhIP is a potent inducer of mutations in the rat prostate where we have shown that it forms bulky DNA adducts. In addition it induces high levels of oxidative damage in the target tissues. The scope of this research includes 1 Generation of a rat model 2 Analysis of the rats prostate after 20 weeks of PhIP and 3 Gene chip microarray analysis. To date we have completed the histopathologic analysis of PhIP induced prostate pathology we have generated an inflammatoryatrophyproliferation model and we have acquired data that refutes a previous model of neoplastic progression. These results have been summarized in a paper submitted to the journal Neoplasia.
- Anatomy and Physiology
- Medicine and Medical Research