Accession Number:

ADA456654

Title:

Preliminary Studies on the Effects of Androstenetriol Induced Immunomodulation in the Treatment of Traumatic Shock

Descriptive Note:

Rept. for 1 Jun 2004-31 May 2005

Corporate Author:

VIRGINIA COMMONWEALTH UNIV RICHMOND

Personal Author(s):

Report Date:

2005-05-31

Pagination or Media Count:

13.0

Abstract:

Specific Aim 1 Examine the ability of androstenetriol to improve survival in a rodent model of combined hemorrhage and tissue injury traumatic shock. Hypothesis 1 The use of androstenetriol shortly after the onset of traumatic shock will improve survival in a rodent model of combined hemorrhage and tissue injury traumatic shock. Specific Aim 2 Examine the ability of androstenetriol to modulate the immune and inflammatory response systemically and in multiple organ systems in response to traumatic shock. Hypothesis 2 The administration of androstenetriol shortly after the onset of traumatic shock will result in changes in the immune and inflammatory response systemically and in individual organ systems which will assist in understanding the mechanisms by which androstenetriol may improve outcome. Specific Aim 3 Examine the ability of androstenetriol to preserve microcirculatory flow and tissue oxygenation during the early stages of traumatic shock Hypothesis 3 The use of androstenetriol shortly after the onset of traumatic shock will be associated with improvements in microcirculatory flow and tissue oxygenation.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE