Accession Number:

ADA456401

Title:

Novel Micro/Nano Approaches for Glucose Measurement Using pH-Sensitive

Descriptive Note:

Annual rept. 1 Jun 2004-31 May 2006

Corporate Author:

LOUISIANA TECH UNIV RUSTON

Personal Author(s):

Report Date:

2006-06-01

Pagination or Media Count:

152.0

Abstract:

This project aims to couple environmentally-sensitive hydrogel materials with immobilized enzymes and two novel readout techniques to develop general platforms for biosensing. The need for improved testing methods for diabetics as well as the potential for use of glucose level as a general marker of metabolic status is the primary motivation for this work. This project is focusing on the use of sensitive transduction schemes that allow reliable detection of small physicalmechanical changes in gel size or water content, specifically microelectromechanical systems MEMS and fluorescence resonance energy transfer RET optical systems. Successful demonstrations of glucose sensing have been accomplished in both areas, and interesting discoveries of hydrogel structure and properties have been uncovered using the novel measurement approaches. The project has generated three published manuscripts and four conference reports.

Subject Categories:

  • Biochemistry
  • Electrical and Electronic Equipment
  • Numerical Mathematics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE