Accession Number:

ADA456364

Title:

Gene Environment Interactions in Women With Breast and Secondary Lung Cancer

Descriptive Note:

Annual summary rept. 1 Jul 2004-30 Jun 2005

Corporate Author:

GEORGETOWN UNIV WASHINGTON DC

Report Date:

2005-07-01

Pagination or Media Count:

17.0

Abstract:

There is significant evidence that indicates an increased risk for developing secondary lung cancer in women treated with radiotherapy for breast cancer and an additional risk for women who smoke. It is important to determine molecular markers for the susceptibility of breast cancer patients to lung cancer to improve information for treatment decisions. Markers in lung cancer may correlate with cancers that develop from radiotherapy alone, in combination with cigarette smoking, or with smoking alone. This project examines p53 mutations, p16 and Ecad methylation, and Estrogen Receptor Alpha as markers of susceptibility to lung cancer after breast cancer. Of 343 tumors assayed, 31 had p53 mutations, 23 had p16 or Ecad methylation, and 186 were Estrogen Receptor Alpha positive. Data generation has been completed for this study and work has progressed to statistical analysis. There may be problems with power due to small sample size in the analysis of subcategory interactions, however, primary hypotheses should be addressable. As this study continues, it will accumulate as many as 600 cases and the hypotheses will be more confidently assessed, providing information that may be useful in defining subpopulations sensitive to radiation therapy.

Subject Categories:

  • Medicine and Medical Research
  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE