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Multiple Aperture Radiation Therapy (MART) to Breast Cancer

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Annual summary rept. 1 Nov 2004-31 Oct 2005

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Compared with conventional methods for breast cancer RT such as opposed tangential fields OTF, modern IMRT provides unprecedented potential to deliver 3D-dose distributions with superior tumor conformality and normal tissue spare. In practice, however, the current IMRT process deviates significantly from the conventional approach and requires considerable costs of the time and health care. The complexity of the treatment and deliver procedure make this technology problematic for the breast radiotherapy. We have carried out a systematic study on a new solution, which is a hybrid of the advantages of the IMRT and OTF, termed as multiple aperture radiotherapy MART. The efficiency in dose shaping and simplicity in dose delivery make it a perfect choice for breast cancer treatment. A number of important milestones have been accomplished, which include i developed an efficient optimization method for MART inverse planning ii implemented MART in a clinic environment for breast treatment iii proposed a gated IMRTMART based on the cutting-edge technology of 4D CT imaging iv established a robust technique for low-dose 4D CT acquisition to reduce the risks of radiation-induced cancer. It is expected these tools will greatly facilitate the imaging, planning, delivery, and quality assurance of breast radiation treatment.

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  • Medicine and Medical Research
  • Radiobiology

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