Targeting Breast Cancer Cells for Destruction
Final rept. 1 Jul 2004-30 Jun 2006
CHILDREN'S HOME HEALTHCARE CINCINNATI OH
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The long-term objective of our work is to understand the actions of existing anti-cancer drugs and to investigate concepts leading to the design of new drugs to eradicate breast cancer. One of our long-standing research interests is in understanding the molecular principles that govern biological specificities. We have been studying both protein-protein interactions and protein-DNA interactions through a battery of different approaches including molecular genetic biochemical and structural approaches. The analysis of molecular principles governing biological specificities is not only important as a basic science problem but also has implications in human health and disease prevention. We have recently investigated the roles of the molecular chaperone Hsp90 in normal development in Drosophila. Hsp90 is a specific target of the anti-cancer druggeldanamycin. Our experiments have identified a new Hsp90 client protein that is critical for normal embryonic development thus establishing a foundation for further investigation of the actions of Hsp90 and the anti-cancer drug geldanamycin. We have also proposed to investigate cellular delivery methods for specifically targeting cancer cells. Our design takes advantage of biological specificities and uses a novel double-targeting system to increase cancer cell specificity.
- Medicine and Medical Research