Effect of Dietary Intervention on Prostate Tumor Development in TRAMP Mice
Annual rept. 1 May 2005-30 Apr 2006
MINNESOTA UNIV AUSTIN HORMEL INST
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Calorie restriction has been reported to protect rodents from many different cancers. With respect to prostate cancer, a protective effect of energy restriction on development of spontaneous prostate tumors in Lobund-Wistar rats and tumors developing from transplanted prostate tumor tissue or cells in mice and rats have been published. However we have found that in female rodents intermittent caloric restriction is more protective than chronic restriction in preventing transgenic mammary tumor development. Here, we determined how intermittent versus chronic calorie restricted affected development of prostate cancer in transgenic TRAMP mice. A 25 reduction in caloric intake is being utilized. Initial findings indicate that intermittent-restricted mice have a significant delay in the age of tumor detection and in the age of death. Evaluation of histopathology is underway and we are attempting to identify a metabolic pathway to target for prevention and treatment strategies. In particular we are assessing aspects of the IGF-I and leptin axes. The results of this study provide further evidence that the manner in which calories are consumed has a significant impact of development of some malignancies.
- Medicine and Medical Research