Accession Number:

ADA456013

Title:

Significance of ERa and c-Src Interaction in the Progression of Hormone Independent Breast Cancer

Descriptive Note:

Final addendum 1 Aug 2004-30 Nov 2005

Corporate Author:

MCGILL UNIV MONTREAL (QUEBEC)

Personal Author(s):

Report Date:

2005-12-01

Pagination or Media Count:

25.0

Abstract:

We have shown previously that c-Src null epithelial cells are unable to respond to estrogenic stimulation 1. In addition, c-Src recruitment to ErbB-2 catalytic domain could be involved in the hormone independent response of ErbB-2 induced mammary tumorigenesis 2. In order to assess whether ablation of c-Src can influence the ability of mammary epithelial cells to respond to hormonal stimulation, we are currently generating a mouse strain homozygous for the loss of c-Src tyrosine kinase specifically in the mammary epithelium. We have also derived several independent mouse strains that express, under the control of an MMTV promoter, a chimeric EGF Receptor TK carrying the catalytic domain of ErbB-2 and thus able to recruit c-Src. Concomitantly, we have generated transgenic mice expressing wild-type EGFR under the transcriptional control of the MMTV promoter. Comparison of the mammary tumor incidence between these mouse strains will provide important insight into the importance of the recruitment of c-Src by ErbB-2 in hormone responsiveness of breast cancers.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE