Accession Number:

ADA455994

Title:

Identification of a Protein for Prostate-Specific Infection

Descriptive Note:

Annual summary, 1 Dec 2004-30 Nov 2005

Corporate Author:

CALIFORNIA UNIV LOS ANGELES

Personal Author(s):

• Pang, Shen

Report Date:

2005-12-01

Pagination or Media Count:

6.0

Abstract:

In this proposal, the authors will identify and clone a protein that can be used to generate an infection-specific gene therapy vector. They expect that by using this protein to modify various gene therapy vectors, they can precisely deliver cytotoxic genes into prostate cancer cells using systemic treatment, and eventually eradicate the metastatic prostate cancer cells in patients. During the second year, they continue screening their cDNA library that they prepared during the first funding year. They have screened approximately 8,000 more colonies, which makes a total of 9,200 colonies screened. They have found that peptides from two genes can efficiently increase lentiviral vectors to infect LNCaP prostate cells. So, in the coming year, they will insert the sequences that encode these two peptides to modify the gene therapy vectors and to generate tissue specific vectors with higher efficacy in gene delivery.

Descriptors:

• *CYTOTOXINS
• *CELLS(BIOLOGY)
• *METASTASIS
• *RETROVIRUSES
• *GENE THERAPY
• *APOPTOSIS
• *PROSTATE CANCER
• PEPTIDES
• PROTEINS
• IDENTIFICATION
• DISEASE VECTORS
• CHEMORECEPTORS
• MEDICAL RESEARCH
• INFECTIOUS DISEASES
• TARGETING
• GENES

Subject Categories:

• Biochemistry
• Genetic Engineering and Molecular Biology
• Medicine and Medical Research
• Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE