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Comparison of the Specificity of MR-EIT and Dynamic Contrast-Enhanced MRI in Breast Cancer
Annual rept. 16 Apr 2005-15 Apr 2006
CALIFORNIA UNIV IRVINE
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It is possible to detect locations of lesions accurately in breast cancer using techniques such as x-ray mammogram accurately however, the specificity of current techniques is low. Since the conductivity values of malignant, benign, and normal tissues are significantly different, this information can be used in classification. Current conductivity imaging techniques can only provide low-resolution images and fail in extreme cases. Magnetic resonance-electrical impedance tomography MREIT is a new modality that can reconstruct high-resolution conductivity images. In this study, we propose the use of MREIT for improving accuracy of breast cancer classification. In the second year of this multidisciplinary post-doctoral training grant, the principal investigator continued to acquire training in breast cancer biology by attending several seminars. She also practiced experimentation and analysis procedures for dynamic contrast enhanced-magnetic resonance imaging DCE-MRI that will be used in the comparative studies in the last year of the project. Simultaneously, the hardware and pulse sequence that is capable of measuring magnetic flux density with low amplitude currents are developed. In our preliminary animal experiments, in vivo MREIT imaging at a safe current level of 1mA is achieved.
APPROVED FOR PUBLIC RELEASE