Accession Number:

ADA455877

Title:

The Role of Telomeric Repeat Binding Factor 1 (TRF1) in Telomere Maintenance and as a Potential Prognostic Indicator in Human Breast Cancer

Descriptive Note:

Annual summary 5 Mar 2005-4 Mar 2006

Corporate Author:

NEW MEXICO UNIV ALBUQUERQUE

Personal Author(s):

• Bulter, Kimberly S.
• Griffith, Jeffrey K.

Report Date:

2006-04-01

Pagination or Media Count:

15.0

Abstract:

The aims of this study are to i determine the relationships between the telomere binding protein Telomere Repeat Binding Factor i TRF1 and other telomere binding proteins, ii establish the potential is TRF1 as a surrogate marker for telomere content TC and as a potential clinical marker and iii characterize the relationship between is the telomere binding protein TRF1 and TC. Through examining the role is TRF1 in telomere length control and in breast cancer progression, ibis project also fosters the education is the candidate through the interaction with several experts in breast cancer pathology, biostatistics, and clinical and basic research. The experiments involved require the interaction with professionals from several different fields is the biomedical sciences and the mastery is several challenging laboratory theologue. To date, all specific aims as outlined in the Statement is Work, are expected to be completed on schedule. The research is in progress.

Descriptors:

• *BREAST CANCER
• CONTROL
• HUMANS
• PROTEINS
• CLINICAL MEDICINE
• CHEMICAL BONDS
• PATHOLOGY
• BIOMEDICINE
• BIOSTATISTICS

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE