Stimulation of Estrogen Receptor Signaling in Breast Cancer by a Novel Chaperone Synuclein Gamma
Annual rept. 1 Jun 2004-31 May 2005
NORTH SHORE - LONG ISLAND JEWISH RESEARCH INST MANHASSET NY
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The association between SNCG expression and the progression of steroid dependent cancers of breast and ovary promoted us to investigate the role of SNCG in regulation of ER . SNCG strongly stimulated the ligand-dependent transcriptional activity of ER in breast cancer cells. A notable finding relevant to this study is that SNCG, acting as a chaperone for ER, strongly stimulated the ligand-dependent transcriptional activity of ER , ligand-dependent cell growth, and ligand-dependent mammary tumorigenesis. Augmentation of SNCG expression stimulated the transcriptional activity of ER and ligand-dependent growth, whereas compromising endogenous SNCG expression suppressed ER signaling and ligand-dependent growth.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research