Accession Number:

ADA455854

Title:

Stimulation of Estrogen Receptor Signaling in Breast Cancer by a Novel Chaperone Synuclein Gamma

Descriptive Note:

Annual rept. 1 Jun 2004-31 May 2005

Corporate Author:

NORTH SHORE - LONG ISLAND JEWISH RESEARCH INST MANHASSET NY

Personal Author(s):

• Shi, Y. E.

Report Date:

2005-06-01

Pagination or Media Count:

23.0

Abstract:

The association between SNCG expression and the progression of steroid dependent cancers of breast and ovary promoted us to investigate the role of SNCG in regulation of ER . SNCG strongly stimulated the ligand-dependent transcriptional activity of ER in breast cancer cells. A notable finding relevant to this study is that SNCG, acting as a chaperone for ER, strongly stimulated the ligand-dependent transcriptional activity of ER , ligand-dependent cell growth, and ligand-dependent mammary tumorigenesis. Augmentation of SNCG expression stimulated the transcriptional activity of ER and ligand-dependent growth, whereas compromising endogenous SNCG expression suppressed ER signaling and ligand-dependent growth.

Descriptors:

• *STIMULATION(PHYSIOLOGY)
• *RECEPTOR SITES(PHYSIOLOGY)
• *ESTROGENS
• *TRANSCRIPTION(GENETICS)
• *BREAST CANCER
• SIGNALS
• LIGANDS
• OVARIES
• STEROIDS
• CELLS(BIOLOGY)
• SENSE ORGANS

Subject Categories:

• Genetic Engineering and Molecular Biology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE