Accession Number:

ADA455789

Title:

BRCA1 Protein Complexes: Dynamic Changes and Functions Important in Breast Cancer

Descriptive Note:

Annual summary rept. 15 Mar 2005-14 Mar 2006

Corporate Author:

HARVARD MEDICAL SCHOOL BOSTON MA

Personal Author(s):

• Horwitz, Andrew

Report Date:

2006-04-01

Pagination or Media Count:

22.0

Abstract:

In the past year, I have made substantial progress towards completion of the tasks outlined in my Statement of Work. I have continued to study the intrinsic transcriptional activity of BRCA1 in the fully purified system, and I have described distinct mechanisms for transcriptional stimulation and repression. These activities recapitulate the in vivo transcriptional functions of BRCA1.

Descriptors:

• *BREAST CANCER
• *TRANSCRIPTION(GENETICS)
• DYNAMICS
• PROTEINS
• PURIFICATION
• IN VIVO ANALYSIS
• CHROMATOGRAPHY
• DISEASE VECTORS
• MASS SPECTROMETRY

Subject Categories:

• Genetic Engineering and Molecular Biology
• Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE