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Accession Number:
ADA455789
Title:
BRCA1 Protein Complexes: Dynamic Changes and Functions Important in Breast Cancer
Descriptive Note:
Annual summary rept. 15 Mar 2005-14 Mar 2006
Corporate Author:
HARVARD MEDICAL SCHOOL BOSTON MA
Report Date:
2006-04-01
Pagination or Media Count:
22.0
Abstract:
In the past year, I have made substantial progress towards completion of the tasks outlined in my Statement of Work. I have continued to study the intrinsic transcriptional activity of BRCA1 in the fully purified system, and I have described distinct mechanisms for transcriptional stimulation and repression. These activities recapitulate the in vivo transcriptional functions of BRCA1.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE