Accession Number:

ADA455778

Title:

Cellular Retinoic Acid Binding Protein and Breast Cancer

Descriptive Note:

Annual summary rept. 14 Apr 2003-13 Apr 2006

Corporate Author:

CORNELL UNIV ITHACA NY

Personal Author(s):

Report Date:

2006-05-01

Pagination or Media Count:

24.0

Abstract:

In attempts to understand how the signaling by retinoic acid the active vitamin A metabolite is regulated we have been studying the retinoic acid binding protein called CRABP-II. These studies revealed that CRABP-II acts to enhance the transcriptional activities of RA and that it does so by directly delivering the hormone to its cognate transcription factor, RAR. Consequently CRABP-II dramatically sensitized cultured mammary carcinoma cells to RA-induced growth inhibition. Similarly, over-expression of CRABP-II inhibited mammary tumor growth in two different mouse models of cancer. CRABP-II may be a novel target for therapeutic and preventive strategies for retinoid-treatment of breast cancer. This project aims to delineate the mechanism by which CRABP-II modulates RA activity, especially as related to its ability to enhance the anti-proliferative action of the ligand.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE