Accession Number:

ADA455731

Title:

Long-Term Outcomes of Alternative Brachytherapy Techniques for Early Prostate Cancer

Descriptive Note:

Annual rept. 30 Dec 2004-29 Dec 2005

Corporate Author:

MASSACHUSETTS GENERAL HOSPITAL BOSTON

Personal Author(s):

• Talcott, James A.

Report Date:

2006-01-01

Pagination or Media Count:

16.0

Abstract:

All active, potentially curative treatments for clinically localized prostate cancer damage quality of life. Brachytherapy,or radioactive seed implants, theoretically may increase the target radiation dose and thus improve control of cancer. has been rapidly adopted in the U.S. despite limited long-term published outcomes, in part because of its convenience apparently attractive toxicity profile. However, our recent survey of brachytherapy patients after longer follow-up surprisingly frequent urinary incontinence and erectile dysfunction. Retrospective evidence suggests that reducing theradiation dose to the urethra may prevent later urinary incontinence. A recent refinement of conventional brachytherapy technique targets only the peripheral zone of the prostate, sharply reducing the dose to the urethra, and attempts to reduce radiation cold spots by using intraoperative feedback from real-time magnetic resonance imagingMRI. Using our validated cancer-specific scales, our pilot data suggested that the altered brachytherapy technique had the intended benefit but also unexpected outcomes. We have extended our cohort study of 276 brachytherapy patients and now compare 3- and 24-month outcomes of this technique to standard ultrasounded-guided brachytherapy.

Descriptors:

• *TOXICITY
• *RADIATION DOSAGE
• *URINARY SYSTEM
• *PROSTATE CANCER
• CONTROL
• COLD REGIONS
• LONG RANGE(TIME)
• DOSAGE
• CURING AGENTS
• PROFILES
• TARGETS
• RADIATION

Subject Categories:

• Medicine and Medical Research
• Radiobiology
• Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE