Accession Number:

ADA455634

Title:

PTEN Regulates Beta-Catenin in Androgen Signaling: Implication in Prostate Cancer Progression

Descriptive Note:

Annual rept. 1 Mar 2005-28 Feb 2006

Corporate Author:

LELAND STANFORD JUNIOR UNIV STANFORD CA

Personal Author(s):

• Sun, Zijie

Report Date:

2006-03-01

Pagination or Media Count:

33.0

Abstract:

The androgen-signaling pathway is essential in male sexual development and in normal and malignant prostate cell growth and survival. PI3KAkt plays a critical role in prostate cancer cell growth and survival. Recent studies demonstrate that the effect of PI3KAkt in prostate cells is mediated through androgen signaling. The PI3K inhibitor, LY294002, and a tumor suppressor, PTEN, negatively regulate the PI3KAkt pathway and repress the androgen receptor AR activity. However, the molecular mechanisms whereby PI3KAkt and PTEN regulate the androgen pathway are currently unclear. During this funding year, we continue examining whether Beta-catenin is a major downstream effector or the PI3KAkt and PTEN pathways in androgen-induced cell growth. Several sets or in vivo and in vitro experiments have been performed in this regard. The results suggest that the interactions between PI3K, Wnt, and androgen pathways are the key events in the tumorigenesis or prostate cancer.

Descriptors:

• *RECEPTOR SITES(PHYSIOLOGY)
• *PROSTATE GLAND
• *ANDROGENS
• *PROSTATE CANCER
• NEOPLASMS
• IN VITRO ANALYSIS
• HYPOTHESES
• GROWTH(PHYSIOLOGY)
• SUPPRESSORS
• IN VIVO ANALYSIS
• CELLS(BIOLOGY)

Subject Categories:

• Biochemistry
• Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE