Ethanol and Mesolimbic Serotonin/Dopamine Interactions Via 5-HT1B Receptors
ILLINOIS UNIV AT CHICAGO
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The experiments were carried out in 5-HT1B receptor knock-out KO mice and wild-type WT mice. One-probe microdialysis was performed. In the first set of experiments, saline or RU 24969 0.5 and 1 mgkg, a 5-HT1B1A receptor agonist, was injected ip to the KO or WT mice. The results showed that administration of RU 24969 at the dose of 1 mgkg significantly increased dopamine DA concentrations in the nucleus accumbens NACC of the WT mice but not the KO mice. In the second set of experiments, saline or ethanol 1 and 2 gkg was injected ip to the KO or WT mice. The results showed that administration of ethanol at the dose of 2 gkg produced more pronounced increases in the NACO DA in the WT mice than in the KO mice. In the third set of experiments, RU 24969 0.5 mgkg was injected ip to KO or WT mice. Twenty min later, each mouse received ethanol injections at the dose of I or 2 gkg. The results showed that pretreatment with RU 24969 enhanced the effects of ethanol on NACO DA in the WT mice but not in the KO mice. These results obtained from transgenic animals provide additional support to the hypothesis that 5-HT1B receptors are partially involved in ethanol-induced increases in mesolimbic DA transmission.
- Stress Physiology
- Organic Chemistry