Accession Number:

ADA455372

Title:

Ultrasound Activated Contrast Imaging for Prostate Cancer Detection

Descriptive Note:

Annual rept. 1 Mar 2005-28 Feb 2006

Corporate Author:

THOMAS JEFFERSON UNIV PHILADELPHIA PA

Personal Author(s):

Report Date:

2006-03-01

Pagination or Media Count:

15.0

Abstract:

The current project proposes todevelop a novel ultrasound contrast imaging technique called EEl for better visualization of the microvessels which are characteristic of the neovasculature associated with prostate cancer. The new zero-thickness interface model was used to simulate the dual pulse imaging mode associated with EEI. While results at an imaging frequency of 7.5 MHz were somewhat in agreement with measurements, the enhancement was unrealistically high 20-35 dB. Further work is ongoing to improve upon the model by incorporating the growth and dissolution of microbubbles. Initial simulation results indicate that the shell elasticity plays a vital role in the growth as well as dissolution of the bubbles. The pulse-echo system was used to perform further in vitro EEI measurements at 7.5 MHz and initial experiments were conducted with 3 contrast agents. The contrast agent Definity produce no enhancement in EEI mode at any of the concentrations studied, while around 6 dB of enhancement was measured with another contrast agent Therimage at the second harmonic frequency at a 20 ll concentration.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Acoustic Detection and Detectors

Distribution Statement:

APPROVED FOR PUBLIC RELEASE