Accession Number:

ADA455360

Title:

Rapid Molecular Fingerprinting of Pathogens

Descriptive Note:

Final rept. 1 Mar 2005-31 May 2006

Corporate Author:

CALIFORNIA UNIV SANTA BARBARA

Personal Author(s):

• Daugherty, Patrick

Report Date:

2006-08-31

Pagination or Media Count:

8.0

Abstract:

The first aim of this project was to identify a set of ligands that bind specifically to each member of a panel of related alpha viruses, namely, equine encephalitis viruses EEV. The second aim was to develop a bacterial cell-based array platform that can be used to detect viruses present in serum or other complex mixtures. During the course of this project we generated a set of peptides that bind to Venezuelan or Western EEV VEEV, WEEV, and investigated a microfluidic array method to pattern these affinity reagent displaying cells into arrays, allowing their potential application for detection assays.

Descriptors:

• *LIGANDS
• *VIRUSES
• DETECTORS
• BACTERIA
• CHEMICAL AGENTS
• PATHOGENIC MICROORGANISMS
• EQUINE ENCEPHALOMYELITIS VIRUS
• ASSAYING
• BINDERS
• PEPTIDES
• PROTEINS

Subject Categories:

• Microbiology
• Organic Chemistry
• Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE