Accession Number:

ADA455316

Title:

Effect of Nifedipine on Core Cooling in Rats during Tail Cold Water Immersion

Descriptive Note:

Journal article

Corporate Author:

ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION

Personal Author(s):

• Durkot, Michael J.
• de Garavilla, Lawrence

Report Date:

2003-09-01

Pagination or Media Count:

5.0

Abstract:

Male rats 450 g, n11group were heated at an ambient temperature of 42 degrees C until a rectal temperature of 42.8 degrees C was attained. The rats then received either saline 30 degrees C tail ice water immersion F I or saline 30 degrees C tail ice water immersion Nifedipine, a peripheral vasodilator F I N to determine cooling rate effectiveness and survivability. The time it took for the rats to reach a rectal temperature of 42.8 degrees C averaged 172 minutes in both groups, resulting in similar heating rates 0.029 degrees Cminute. The cooling rates in group F I and F I N were not significantly different from each other. The authors conclude that since Nifedipine did not improve cooling rates when combined with fluid tail ice water immersion, its use as a cooling adjunct does not seem warranted.

Descriptors:

• *RATS
• *COOLING
• *THERAPY
• *HYPERTHERMIA
• *VASODILATION
• *COLD WATER
• *DRUGS
• REPRINTS
• HEAT STRESS(PHYSIOLOGY)
• HEAT STROKE
• RECTUM
• VASOCONSTRICTING
• SALINE SOLUTION
• MALES
• PHYSIOLOGICAL EFFECTS
• IMMERSION
• ICE
• SURVIVABILITY

Subject Categories:

• Medicine and Medical Research
• Stress Physiology
• Pharmacology
• Thermodynamics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE