Effect of Nifedipine on Core Cooling in Rats during Tail Cold Water Immersion
ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
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Male rats 450 g, n11group were heated at an ambient temperature of 42 degrees C until a rectal temperature of 42.8 degrees C was attained. The rats then received either saline 30 degrees C tail ice water immersion F I or saline 30 degrees C tail ice water immersion Nifedipine, a peripheral vasodilator F I N to determine cooling rate effectiveness and survivability. The time it took for the rats to reach a rectal temperature of 42.8 degrees C averaged 172 minutes in both groups, resulting in similar heating rates 0.029 degrees Cminute. The cooling rates in group F I and F I N were not significantly different from each other. The authors conclude that since Nifedipine did not improve cooling rates when combined with fluid tail ice water immersion, its use as a cooling adjunct does not seem warranted.
- Medicine and Medical Research
- Stress Physiology