Accession Number:

ADA455282

Title:

Breast Cancer Detection Using Optical Vascular Fusion

Descriptive Note:

Final rept. 13 May 2002-12 May 2005

Corporate Author:

SRI INTERNATIONAL MENLO PARK CA

Personal Author(s):

• Faris, Gregory W.

Report Date:

2005-06-01

Pagination or Media Count:

52.0

Abstract:

We are investigating a new approach to detection of breast cancer using optical vascular function imaging. Research on cancer therapy has revealed unusual properties of tumor vasculature produced through angiogenesis that have high promise for breast cancer detection. We are using this unusual behavior as a contrast mechanism by performing optical imaging during administration of different levels of oxygen and carbon dioxide. We have constructed imaging systems using immersion in a tissue phantom, improved the sensitivity and speed of the imaging systems and used mass flow controllers to regulate inhalation gas compositions, imaged 5 different cancer models, and compared dynamic and static measurements. Our results support our hypothesis that the additional contrast from imaging vascular function is superior to static conventional optical imaging. The results of this IDEA project have been the basis of additional funding for clinical testing. We believe that this approach can form the basis for a cancer imaging modality combining high sensitivity and specificity. New, sensitive, specific, and low cost imaging technologies are very important for detection and treatment of breast cancer, and should lead to reduced morbidity and mortality from this disease.

Descriptors:

• *OPTICAL IMAGES
• *BREAST CANCER
• IMAGE PROCESSING
• DIAGNOSIS(MEDICINE)
• CANCER SCREENING
• ANGIOGENESIS
• CARBON DIOXIDE
• CARDIOVASCULAR SYSTEM
• HIGH SENSITIVITY

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE