Prostate Cancer Aggressiveness Genes in Hereditary Prostate Cancer
Annual rept. 1 Mar 2005-28 Feb 2006
MICHIGAN UNIV ANN ARBOR
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The EZH2 transcriptional regulator, recently shown by to be overexpressed in prostate cancer specimens that are more likely to recur, maps to 7q35 and represents a candidate gene for inherited prostate cancer susceptibility. This statement is based on the identification of prostate cancer linkage to distal 7q markers in a recently completed genome-wide scan using hereditary prostate cancer families from the University of Michigan Prostate Cancer Genetics Project PCGP. Relatively little is known about the molecular basis of EZH2 function or its DNA specificity. The major hypothesis of this proposal is that germline mutations in the EZH2 gene will predispose to more clinically aggressive forms of prostate cancer and the characterization of these mutations will provide more information about the function of the EZH2 molecule in prostate cancer and metastasis. To address this hypothesis, the following two specific aims were proposed 1 to identify germline mutations in EZH2 that predispose to aggressive prostate cancer in prostate cancer families, and 2 to characterize the functional consequences of EZH2 mutations specifically focusing on the role of EZH2 in transcriptional regulation.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research
- Stress Physiology