Structure Optimization of 21,23-Core-Modified Porphyrins Absorbing Long-Wavelength Light as Potential Photosensitizers Against Breast Cancer Cells
Annual rept. 1 Apr 2005-31 Mar 2006
STATE UNIV OF NEW YORK AT ALBANY
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In the first year we made eighteen new 21 23-core modified porphydns determined their photophysical properbes and evaluated the biological properties of them. In the second year the research had been focused on 1 analyzing quantitative structure-activity relationships QSAR of the porphyrins prepared in the first year using mathematical models 2 measuring specific binding to peripheral benzodiazepine receptors PBR and 3 establishing new synthetic methods for novel structures and preparing them. From QSAR analysis we found that the theoretical lipophilicity MiLog P was the major factor for their phototoxicity in general the molecular size was important at least in the core- modified porphyrins having two carboxylic acids. Unfortunately we could not detect any specific binding of the most potent compound toward PBR. In the synthetic part we successfully prepared eleven compounds of novel structures. The evaluation of them photophysically and biologically will be the major subjects of the third year in the project.
- Anatomy and Physiology
- Medicine and Medical Research