Targeting Killing of Breast Tumor Stem Cells
Final rept. 15 Aug 2003-14 Aug 2005
BAYLOR COLL OF MEDICINE HOUSTON TX
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It has been postulated that the heterogeneous, metastatic breast cancer cells are originated from a single or a small number of distinct tumor stem cells, and that only the cancer stem cells have the unlimited ability to proliferate and metastasize to different tissues and organs. A recent study found that the CD44CD24- breast tumor cells may be breast tumor stem cells. CD44 is a receptor that binds to hyaluronan HA, a carbohydrate consisting of 1,3 N-acetyl glucosaminyl- 1,4 glucuronide. We have proposed to generate CD44-targeted liposome to selectively destroy the CD44 breast tumor cells. Toward the goal, we have prepared HA molecules from human umbilical cord hyaluronic acid by hydrolysed by Bee venom. However, we have encountered the technical difficulty to produce CD44-targeted liposomes that are incorporated with HA molecules. Due to the technical problems, this proposed study has been extended for additional one year.
- Medicine and Medical Research