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Examining the Effects of Exercise Training on Tumor Response to Nithracycline-Based Chemotherapy
Final rept. 15 Jul 2003-14 Jul 2005
ALBERTA UNIV EDMONTON
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Exercise is becoming readily accepted as a beneficial adjunct therapy to maintain or enhance quality of life in breast cancer patients during adjuvant chemotherapy. An essential precursor to these studies is to investigate whether exercise modulates the antitumor efficacy of chemotherapeutic agents. Athymic female mice were transplanted with MDA-MB-231 breast xenografts and randomly assigned to one of four groups n 21 per group i control, ii exercise only, iii doxorubicin only, or iv exercise doxorubicin. Exercise groups performed progressive treadmill running up to 18mmin at 0 grade for 45mins, 5 dayswk for 8 weeks. Tumor growth delay was significantly longer in the doxorubicin only and exercise doxorubicin groups compared with the control median 42 vs. 25 days, p0.0082 36 vs. 25 days, p0.029, respectively and exercise only groups median 42 vs. 25 days, p0.029 36 vs. 25 days, p0.080, respectively. There was no significant difference between doxorubicin only and exercise doxorubicin groups median 42 vs. 36 days, p0.33 suggesting that moderate intensity exercise does not significantly influence doxorubicin-induced tumor growth delay.
APPROVED FOR PUBLIC RELEASE